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Effects of magnesium stearate on the efficient dispersion of salbutamol sulphate from carrier-based dry powder inhaler formulations

Islam, Nazrul, Rashid, Abdul, & Camm, Gaye (2011) Effects of magnesium stearate on the efficient dispersion of salbutamol sulphate from carrier-based dry powder inhaler formulations. In Proceedings of RDD Europe 2011, Volume II, Respiratory Drug Delivery (RDD) Online / Virginia Commonwealth University , Berlin, Germany, pp. 415-418.

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Abstract

Dry powder inhaler (DPI) formulations is one of the most useful aerosol preparations in which drugs may be formulated as carrier-based interactive mixtures with micronised drug particles (<5 μm) adhered onto the surface of large inert carriers (lactose powders). The addition of magnesium stearate (MgSt) (1-3), was found to increase dispersion of various drugs from DPI formulations. Recently, some active compounds coated with 5% (wt/wt) MgSt using the mechanofusion method showed significant improvements in aerosolization behavior due to the reduction in intrinsic cohesion force (4). Application of MgSt in powder formulations is not new; however, no studies demonstrated the minimum threshold level for this excipient in efficient aerosolization of drug powders from the interactive mixtures. Therefore, this study investigated the role of MgSt concentration on the efficient dispersion of salbutamol sulphate (SS) from DPI formulations.

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ID Code: 40722
Item Type: Conference Paper
Keywords: magnesium stearate, lactose carrier, agglomeration, particle interactions, powder coating, dry powder inhalation
ISBN: 1-933722-51-7
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Pharmaceutical Sciences (111504)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Pharmacy
Copyright Owner: Copyright 2011 please consult the authors
Deposited On: 14 Mar 2011 11:57
Last Modified: 15 May 2012 07:43

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