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Chlamydia muridarum major outer membrane protein-specific antibodies inhibit in vitro infection but enhance pathology in vivo

Cunningham, Kelly, Carey, Alison, Hafner, Louise M., Timms, Peter, & Beagley, Kenneth W. (2011) Chlamydia muridarum major outer membrane protein-specific antibodies inhibit in vitro infection but enhance pathology in vivo. American Journal of Reproductive Immunology, 65(2), pp. 118-126.

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Abstract

PROBLEM

Chlamydia trachomatis is a significant worldwide health problem, and the often-asymptomatic disease can result in infertility. To develop a successful vaccine, a complete understanding of the immune response to chlamydial infection and development of genital tract pathology is required.

METHOD OF STUDY

We utilized the murine genital model of chlamydial infection. Mice were immunized with chlamydial major outer membrane protein, and vaginal lavage was assessed for the presence of neutralizing antibodies. These samples were then pre-incubated with Chlamydia muridarum and administered to the vaginal vaults of immune-competent female BALB/c mice to determine the effect on infection.

RESULTS

The administration of C. muridarum in conjunction with neutralizing antibodies reduced the numbers of mice infected, but a surprising finding was that this accelerated the development of severe oviduct pathology.

CONCLUSION

Antibodies play an under-recognized role in chlamydial infection and pathology development, which possibly involves interaction with Th1 immunity.

Impact and interest:

5 citations in Scopus
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3 citations in Web of Science®

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Full-text downloads:

24 since deposited on 21 Mar 2011
8 in the past twelve months

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ID Code: 40829
Item Type: Journal Article
Keywords: Chlamydia, Infecion, Pathology, Mouse model
DOI: 10.1111/j.1600-0897.2010.00894.x
ISSN: 1046-7408
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Past > Schools > Cell & Molecular Biosciences
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 John Wiley & Sons A/S
Deposited On: 22 Mar 2011 07:52
Last Modified: 04 Feb 2014 09:06

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