Preparation of mesoporous bioglass coated zirconia scaffold for bone tissue engineering

Lin, Feng, Yan, Cheng, Zheng, Wei, Fan, Wei, Adam, Clayton J., & Oloyede, Adekunle (2010) Preparation of mesoporous bioglass coated zirconia scaffold for bone tissue engineering. In Zhou, Xueli (Ed.) Proceedings of the 2010 First International Conference on Cellular, Molecular Biology, Biophysics and Bioengineering (CMBB), IEEE, Jiangxi Qixing Commercial Hotel, Qiqihar, China, 330-334 .

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Porous yttria-stabilized zirconia (YSZ) has been regarded as a potential candidate for bone substitute due to its high mechanical strength. However, porous YSZ is biologically inert to bone tissue. It is therefore necessary to introduce bioactive coatings onto the walls of the porous structures to enhance its bioactivity. In this study, porous YSZ scaffolds were prepared using a replication technique and then coated with mesoporous bioglass due to its excellent bioactivity. The microstructures were examined using scanning electron microscopy and the mechanical strength was evaluated via compression test. The biocompatibility and bioactivity were also evaluated using bone marrow stromal cell (BMSC) proliferation test and simulated body fluid test.

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ID Code: 40943
Item Type: Conference Paper
Refereed: Yes
Additional URLs:
Keywords: Scaffold, Porous Structure, Mesoporous Bioglass, Zirconia (YSZ), Compression Strength, Tissue Engineering, Mechanical Property, Bone
ISBN: 9781424491582
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Ceramics (091201)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 IEEE.
Copyright Statement: Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Deposited On: 24 Mar 2011 23:08
Last Modified: 13 Apr 2014 23:33

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