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Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait

Wilcox, Robert A., Cole, Michael H., Wong, David, Coyne, Terry, Silburn, Peter A., & Kerr, Graham K. (2010) Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait. Journal of Neurology, Neurosurgery and Psychiatry, pp. 1-4.

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Abstract

Objective: To assess the efficacy of bilateral pedunculopontine nucleus (PPN) deep brain stimulation (DBS) as a treatment for primary progressive freezing of gait (PPFG). ------ -----

Methods: A patient with PPFG underwent bilateral PPN-DBS and was followed clinically for over 14 months. ------ -----

Results: The PPFG patient exhibited a robust improvement in gait and posture following PPN-DBS. When PPN stimulation was deactivated, postural stability and gait skills declined to pre-DBS levels, and fluoro-2-deoxy-d-glucose positron emission tomography revealed hypoactive cerebellar and brainstem regions, which significantly normalised when PPN stimulation was reactivated. ------ -----

Conclusions: This case demonstrates that the advantages of PPN-DBS may not be limited to addressing freezing of gait (FOG) in idiopathic Parkinson's disease. The PPN may also be an effective DBS target to address other forms of central gait failure.

Impact and interest:

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15 citations in Web of Science®

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ID Code: 41044
Item Type: Journal Article
Additional Information: Funding This study was self-funded by the authors as an extension of the patient's clinical management and not supported by specific funding. RAW, TC and PS received financial support from Medtronic Australasia to attend the Australasian Deep Brain Stimulation Meeting in 2009.
Additional URLs:
Keywords: Pedunculopontine Nucleaus, Deep Brain Stimulation, Gait, Balance
DOI: 10.1136/jnnp.2010.213462
ISSN: 0022-3050
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Motor Control (110603)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurology and Neuromuscular Diseases (110904)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Copyright Article author (or their employer) 2010. Produced by BMJ Publishing Group Ltd under licence.
Deposited On: 29 Mar 2011 17:17
Last Modified: 01 Mar 2012 00:24

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