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Mesenchymal stem cells in osteoarthritis therapy : current status of theory, technology, and applications

Prasadam, Indira, Chakravorty, Nishant, Crawford, Ross W., & Xiao, Yin (2012) Mesenchymal stem cells in osteoarthritis therapy : current status of theory, technology, and applications. In Xiao, Yin (Ed.) Mesenchymal Stem Cells. NOVA Science Publishers, Inc, New York, 163-176 .

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    Abstract

    Osteoarthritis (OA) is a chronic, non-inflammatory type of arthritis, which usually affects the movable and weight bearing joints of the body. It is the most common joint disease in human beings and common in elderly people. Till date, there are no safe and effective diseases modifying OA drugs (DMOADs) to treat the millions of patients suffering from this serious and debilitating disease. However, recent studies provide strong evidence for the use of mesenchymal stem cell (MSC) therapy in curing cartilage related disorders. Due to their natural differentiation properties, MSCs can serve as vehicles for the delivery of effective, targeted treatment to damaged cartilage in OA disease. In vitro, MSCs can readily be tailored with transgenes with anti-catabolic or pro-anabolic effects to create cartilage-friendly therapeutic vehicles. On the other hand, tissue engineering constructs with scaffolds and biomaterials holds promising biological cartilage therapy. Many of these strategies have been validated in a wide range of in vitro and in vivo studies assessing treatment feasibility or efficacy. In this review, we provide an outline of the rationale and status of stem-cell-based treatments for OA cartilage, and we discuss prospects for clinical implementation and the factors crucial for maintaining the drive towards this goal.

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    ID Code: 41117
    Item Type: Book Chapter
    Additional URLs:
    Keywords: osteoarthritis, stem cells, mesenchymal , cell therapy, cartilage
    ISBN: 9781613246696
    Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)
    Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
    Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
    Current > Institutes > Institute of Health and Biomedical Innovation
    Past > Schools > School of Engineering Systems
    Copyright Owner: Copyright 2011 NOVA Science Publishers, Inc
    Deposited On: 05 May 2011 07:49
    Last Modified: 06 Jun 2013 17:56

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