QUT ePrints

Corrected mean-field models for spatially-dependent advection-diffusion-reaction phenomena

Simpson, Matthew & Baker, Ruth (2011) Corrected mean-field models for spatially-dependent advection-diffusion-reaction phenomena. Physical Review E, 83(5), 051922-1--051922-15.

View at publisher

Abstract

In the exclusion-process literature, mean-field models are often derived by assuming that the occupancy status of lattice sites is independent. Although this assumption is questionable, it is the foundation of many mean-field models. In this work we develop methods to relax the independence assumption for a range of discrete exclusion process-based mechanisms motivated by applications from cell biology. Previous investigations that focussed on relaxing the independence assumption have been limited to studying initially-uniform populations and ignored any spatial variations. By ignoring spatial variations these previous studies were greatly simplified due to translational invariance of the lattice. These previous corrected mean-field models could not be applied to many important problems in cell biology such as invasion waves of cells that are characterised by moving fronts. Here we propose generalised methods that relax the independence assumption for spatially inhomogeneous problems, leading to corrected mean-field descriptions of a range of exclusion process-based models that incorporate

(i) unbiased motility, (ii) biased motility, and (iii) unbiased motility with agent birth and death processes.

The corrected mean-field models derived here are applicable to spatially variable processes including invasion wave type problems. We show that there can be large deviations between simulation data and traditional mean-field models based on invoking the independence assumption. Furthermore, we show that the corrected mean-field models give an improved match to the simulation data in all cases considered.

Impact and interest:

18 citations in Scopus
Search Google Scholar™
16 citations in Web of Science®

Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

57 since deposited on 11 Apr 2011
12 in the past twelve months

Full-text downloadsdisplays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 41183
Item Type: Journal Article
Keywords: cellular automata, exclusion process, mean-field, correlation
DOI: 10.1103/PhysRevE.83.051922
ISSN: 1539-3755
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2011 American Physical Society
Deposited On: 11 Apr 2011 15:17
Last Modified: 05 Jan 2012 10:06

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page