Temporal tissue patterns in bone healing of sheep

Vetter, Andreas, Epari, Devakara R., Seidel, Robin, Schell, Hanna, Fratzl, Peter, Duda, Georg N., & Weinkamer, Richard (2010) Temporal tissue patterns in bone healing of sheep. Journal of Orthopaedic Research, 28(11), p. 1440.

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Secondary fracture healing in long bones leads to the successive formation of intricate patterns of tissues in the newly formed callus. The main aim of this work was to quantitatively describe the topology of these tissue patterns at different stages of the healing process and to generate averaged images of tissue distribution. This averaging procedure was based on stained histological sections (2, 3, 6, and 9 weeks post-operatively) of 64 sheep with a 3 mm tibial mid-shaft osteotomy, stabilized either with a rigid or a semi-rigid external fixator. Before averaging, histological images were sorted for topology according to six identified tissue patterns. The averaged images were obtained for both fixation types and the lateral and medial side separately. For each case, the result of the averaging procedure was a collection of six images characterizing quantitatively the progression of the healing process. In addition, quantified descriptions of the newly formed cartilage and the bone area fractions (BA/TA) of the bony callus are presented. For all cases, a linear increase in the BA/TA of the bony callus was observed. The slope was greatest in the case of the most rigid stabilization and lowest in the case of the least stiff. This topological description of the progression of bone healing will allow quantitative validation (or falsification) of current mechano-biological theories.

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18 citations in Scopus
16 citations in Web of Science®
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ID Code: 41295
Item Type: Journal Article
Refereed: Yes
DOI: 10.1002/jor.21175
ISSN: 07360266
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright © 2010 Orthopaedic Research Society.
Deposited On: 15 Apr 2011 04:43
Last Modified: 29 Feb 2012 14:25

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