Can the contra-lateral limb be used as a control with respect to analyses of bone remodelling?
Krishnakanth, Pushpanjali, Schmutz, Beat, Steck, Roland, Mishra, Sanjay K., Schuetz, Michael, & Epari, Devakara R. (2011) Can the contra-lateral limb be used as a control with respect to analyses of bone remodelling? Medical Engineering and Physics, 33(8), pp. 987-992.
Bone loss may result from remodelling initiated by implant stress protection. Quantifying remodelling requires bone density distributions which can be obtained from computed tomography scans. Pre-operative scans of large animals however are rarely possible. This study aimed to determine if the contra-lateral bone is a suitable control for the purpose of quantifying bone remodelling. CT scans of 8 pairs of ovine tibia were used to determine the likeness of left and right bones. The deviation between the outer surfaces of the bone pairs was used to quantify geometric similarity. The density differences were determined by dividing the bones into discrete volumes along the shaft of the tibia. Density differences were also determined for fractured and contra-lateral bone pairs to determine the magnitude of implant related remodelling. Left and right ovine tibiae were found to have a high degree of similarity with differences of less than 1.0 mm in the outer surface deviation and density difference of less than 5% in over 90% of the shaft region. The density differences (10–40%) as a result of implant related bone remodelling were greater than left-right differences. Therefore, for the purpose of quantifying bone remodelling in sheep, the contra-lateral tibia may be considered an alternative to a pre-operative control.
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|Item Type:||Journal Article|
|Keywords:||ovine, tibia, computer tomography, bone remodelling, contra-lateral|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
|Copyright Owner:||Copyright 2011 Elsevier|
|Deposited On:||27 Apr 2011 10:26|
|Last Modified:||31 Mar 2013 04:41|
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