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Diversity of community acquired MRSA carrying the PVL gene in Queensland and New South Wales, Australia

Costello, Mary-Ellen Clare & Huygens, Flavia (2011) Diversity of community acquired MRSA carrying the PVL gene in Queensland and New South Wales, Australia. European Journal of Clinical Microbiology & Infectious Diseases.

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Abstract

Emergence and dissemination of community acquired methicillin resistant Staphylococcus aureus (CA-MRSA) strains are being reported with increasing frequency in Australia and worldwide. These strains of CA-MRSA are genetically diverse and distinct in Australia. Genotyping of CA-MRSA using eight highly-discriminatory single nucleotide polymorphisms (SNPs) is a rapid and robust method for monitoring the dissemination of these strains in the community. In this study, a SNP genotyping method was used to investigate the molecular epidemiology of 249 community acquired non-multiresistant MRSA (nm-MRSA) isolates over a 12-month period from routine diagnostic specimens. A real-time PCR for the presence of Panton-Valentine leukocidin (PVL) was also performed on these isolates. The CA-MRSA isolates were sourced from a large private laboratory in Brisbane, Australia that serves a wide geographic region encompassing Queensland and Northern New South Wales. This study identified 16 different STs and 98% of the CA-MRSA isolates were positive for the PVL gene. The most common ST was ST93 with 41% of isolates testing positive for this clone.

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6 citations in Scopus
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4 citations in Web of Science®

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ID Code: 41424
Item Type: Journal Article
Additional Information: Springer Online First Publication
Additional URLs:
Keywords: Staphylococcus aureus, CA-MRSA, single nucleotide polymorphisms, SNPs
DOI: 10.1007/s10096-011-1203-4
ISSN: 0934-9723
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL MICROBIOLOGY (110800)
Divisions: Past > Schools > Cell & Molecular Biosciences
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Springer
Deposited On: 27 Apr 2011 08:27
Last Modified: 02 Jun 2011 01:00

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