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A mathematical model of chlamydial infection incorporating movement of chlamydial particles

Mallet, Dann G., Bagher-Oskouei, Masoumeh, Farr, Anna Charisse, Simpson, Daniel Peter, & Heymer, Kelly-Jean (2013) A mathematical model of chlamydial infection incorporating movement of chlamydial particles. Bulletin of Mathematical Biology, 75(11), pp. 2257-2270.

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    Abstract

    We present a spatiotemporal mathematical model of chlamydial infection, host immune response and spatial movement of infectious particles. The re- sulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous chlamydia modelling by incorporating spatial change, which we also demonstrate to be essential when the timescale for movement of infectious particles is equal to, or shorter than, the developmental cycle timescale. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.

    Impact and interest:

    3 citations in Scopus
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    1 citations in Web of Science®

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    ID Code: 41766
    Item Type: Journal Article
    Keywords: chlamydia, partial differential equation, mathematical model, infectious diseases
    DOI: 10.1007/s11538-013-9891-9
    ISSN: 0092-8240
    Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
    Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
    Current > Institutes > Institute of Health and Biomedical Innovation
    Past > Schools > Mathematical Sciences
    Copyright Owner: Copyright 2011 Springer
    Copyright Statement: The original publication will be available at SpringerLink http://www.springerlink.com
    Deposited On: 23 May 2011 08:13
    Last Modified: 07 Nov 2013 08:59

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