A mathematical model of chlamydial infection incorporating movement of chlamydial particles

Mallet, Dann G., Bagher-Oskouei, Masoumeh, Farr, Anna Charisse, Simpson, Daniel Peter, & Sutton, Kelly-Jean (2013) A mathematical model of chlamydial infection incorporating movement of chlamydial particles. Bulletin of Mathematical Biology, 75(11), pp. 2257-2270.

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We present a spatiotemporal mathematical model of chlamydial infection, host immune response and spatial movement of infectious particles. The re- sulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous chlamydia modelling by incorporating spatial change, which we also demonstrate to be essential when the timescale for movement of infectious particles is equal to, or shorter than, the developmental cycle timescale. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility.

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7 citations in Scopus
6 citations in Web of Science®
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248 since deposited on 22 May 2011
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ID Code: 41766
Item Type: Journal Article
Refereed: Yes
Keywords: chlamydia, partial differential equation, mathematical model, infectious diseases
DOI: 10.1007/s11538-013-9891-9
ISSN: 0092-8240
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2011 Springer
Copyright Statement: The original publication will be available at SpringerLink http://www.springerlink.com
Deposited On: 22 May 2011 22:13
Last Modified: 19 Feb 2015 04:54

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