Ghrelin axis genes, peptides and receptors : recent findings and future challenges
Seim, Inge, Josh, Peter, Cunningham, Peter, Herington, Adrian, & Chopin, Lisa (2011) Ghrelin axis genes, peptides and receptors : recent findings and future challenges. Molecular and Cellular Endocrinology. (In Press)
The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also clear that the locus encodes a range of other bioactive molecules, including novel peptides and non-coding RNAs. For many of these molecules, the physiological functions and cognate receptor(s) remain to be determined. Emerging research techniques, including proteogenomics, are likely to reveal further ghrelin axis-derived molecules. Studies of the role of ghrelin-axis genes, peptides and receptors, therefore, promises to be a fruitful area of basic and clinical research in years to come.
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|Item Type:||Journal Article|
|Additional Information:||Elsevier First Online publishing|
|Keywords:||ghrelin gene, ghrelin preprohormone, obestatin, antisense genes|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2011 Elsevier|
|Deposited On:||01 Jun 2011 07:23|
|Last Modified:||24 Jun 2011 13:50|
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