Ghrelin axis genes, peptides and receptors : recent findings and future challenges
Seim, Inge, Josh, Peter, Cunningham, Peter, Herington, Adrian, & Chopin, Lisa (2011) Ghrelin axis genes, peptides and receptors : recent findings and future challenges. Molecular and Cellular Endocrinology. (In Press)
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Abstract
The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also clear that the locus encodes a range of other bioactive molecules, including novel peptides and non-coding RNAs. For many of these molecules, the physiological functions and cognate receptor(s) remain to be determined. Emerging research techniques, including proteogenomics, are likely to reveal further ghrelin axis-derived molecules. Studies of the role of ghrelin-axis genes, peptides and receptors, therefore, promises to be a fruitful area of basic and clinical research in years to come.
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| ID Code: | 41847 |
|---|---|
| Item Type: | Journal Article |
| Additional Information: | Elsevier First Online publishing |
| Keywords: | ghrelin gene, ghrelin preprohormone, obestatin, antisense genes |
| DOI: | 10.1016/j.mce.2011.05.002 |
| ISSN: | 0303-7207 |
| Subjects: | Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Science and Technology Current > Institutes > Institute of Health and Biomedical Innovation |
| Copyright Owner: | Copyright 2011 Elsevier |
| Deposited On: | 01 Jun 2011 07:23 |
| Last Modified: | 24 Jun 2011 13:50 |
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