Ghrelin axis genes, peptides and receptors : recent findings and future challenges

Seim, Inge, Josh, Peter, Cunningham, Peter, Herington, Adrian, & Chopin, Lisa K. (2011) Ghrelin axis genes, peptides and receptors : recent findings and future challenges. Molecular and Cellular Endocrinology, 340(1), pp. 3-9.

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The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also clear that the locus encodes a range of other bioactive molecules, including novel peptides and non-coding RNAs. For many of these molecules, the physiological functions and cognate receptor(s) remain to be determined. Emerging research techniques, including proteogenomics, are likely to reveal further ghrelin axis-derived molecules. Studies of the role of ghrelin axis genes, peptides and receptors, therefore, promises to be a fruitful area of basic and clinical research in years to come.

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ID Code: 41847
Item Type: Journal Article
Refereed: Yes
Keywords: ghrelin gene, ghrelin preprohormone, obestatin, antisense genes
DOI: 10.1016/j.mce.2011.05.002
ISSN: 0303-7207
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Elsevier
Copyright Statement: This is the author’s version of a work that was accepted for publication in Molecular and Cellular Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Molecular and Cellular Endocrinology, [VOL 340, ISSUE 1, (2011)] DOI: 10.1016/j.mce.2011.05.002
Deposited On: 31 May 2011 21:23
Last Modified: 06 Nov 2013 02:54

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