The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease

Seim, Inge, Walpole, Carina, Amorim, Laura, Josh, Peter, Herington, Adrian, & Chopin, Lisa (2011) The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease. Molecular and Cellular Endocrinology.

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Obestatin is a 23 amino acid, ghrelin gene-derived peptide hormone produced in the stomach and a range of other tissues throughout the body. While it was initially reported that obestatin opposed the actions of ghrelin with regards to appetite and food intake, it is now clear that obestatin is not an endogenous ghrelin antagonist of ghrelin, but it is a multi-functional peptide hormone in its own right. In this review we will discuss the controversies associated with the discovery of obestatin and explore emerging central and peripheral roles of obestatin, roles in adipogenesis, pancreatic homeostasis and cancer.

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ID Code: 41849
Item Type: Journal Article
Refereed: Yes
Additional Information: Elsevier First Online publishing
Keywords: ghrelin gene, ghrelin preprohormone, obestatin
DOI: 10.1016/j.mce.2011.03.018
ISSN: 0303-7207
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 Elsevier
Deposited On: 30 May 2011 22:26
Last Modified: 26 Jun 2011 11:13

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