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Spatially offset Raman spectroscopy (SORS) for the analysis and detection of packaged pharmaceuticals and concealed drugs

Olds, William J., Jaatinen, Esa, Fredericks, Peter M., Cletus, Biju, Panayiotou, Helen, & Izake, Emad L. (2011) Spatially offset Raman spectroscopy (SORS) for the analysis and detection of packaged pharmaceuticals and concealed drugs. Forensic Science International, 212(1), pp. 69-77.

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Abstract

Spatially offset Raman spectroscopy (SORS) is a powerful new technique for the non-invasive detection and identification of concealed substances and drugs. Here, we demonstrate the SORS technique in several scenarios that are relevant to customs screening, postal screening, drug detection and forensics applications. The examples include analysis of a multi-layered postal package to identify a concealed substance; identification of an antibiotic capsule inside its plastic blister pack; analysis of an envelope containing a powder; and identification of a drug dissolved in a clear solvent, contained in a non-transparent plastic bottle. As well as providing practical examples of SORS, the results highlight several considerations regarding the use of SORS in the field, including the advantages of different analysis geometries and the ability to tailor instrument parameters and optics to suit different types of packages and samples. We also discuss the features and benefits of SORS in relation to existing Raman techniques, including confocal microscopy, wide area illumination and the conventional backscattered Raman spectroscopy. The results will contribute to the recognition of SORS as a promising method for the rapid, chemically-specific analysis and detection of drugs and pharmaceuticals.

Impact and interest:

18 citations in Scopus
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18 citations in Web of Science®

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ID Code: 41989
Item Type: Journal Article
Additional URLs:
Keywords: Raman spectroscopy, Laser, Pharmaceutical analysis, Forensic analysis, Drug detection, Spatially offset Raman spectroscopy, SORS
DOI: 10.1016/j.forsciint.2011.05.016
ISSN: 0379-0738
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OPTICAL PHYSICS (020500) > Lasers and Quantum Electronics (020502)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OPTICAL PHYSICS (020500) > Nonlinear Optics and Spectroscopy (020503)
Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > ANALYTICAL CHEMISTRY (030100) > Instrumental Methods (excl. Immunological and Bioassay Methods) (030105)
Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > ANALYTICAL CHEMISTRY (030100) > Sensor Technology (Chemical aspects) (030107)
Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > PHYSICAL CHEMISTRY (INCL. STRUCTURAL) (030600) > Physical Chemistry not elsewhere classified (030699)
Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > OTHER CHEMICAL SCIENCES (039900) > Forensic Chemistry (039902)
Divisions: Past > Schools > Chemistry
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Physics
Copyright Owner: Copyright 2011 Elsevier Ireland Ltd
Copyright Statement: NOTICE: this is the author’s version of a work that was accepted for publication in Forensic Science International. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Forensic Science International, [Volume 212, Issues 1–3, (10 October 2011)] DOI: 10.1016/j.forsciint.2011.05.016
Deposited On: 16 Jun 2011 10:00
Last Modified: 13 Sep 2013 16:12

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