Porous zirconia scaffold modified with mesoporous bioglass coating

Lin, Feng, Yan, Cheng, & Adam, Clayton J. (2011) Porous zirconia scaffold modified with mesoporous bioglass coating. In The First International Postgraduate Conference on Engineering, Designing and Developing the Built Environment for Sustainable Wellbeing, 27-29 April 2011, Queensland University of Technology, Brisbane, Qld.

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Porous yttria-stabilized zirconia (YSZ) has been regarded as a potential candidate for bone substitute as its high mechanical strength. However, porous YSZ bodies are biologically inert to bone tissue. It is therefore necessary to introduce bioactive coatings onto the walls of the porous structures to enhance the bioactivity. In this study, the porous zirconia scaffolds were prepared by infiltration of Acrylonitrile Butadiene Styrene (ABS) scaffolds with 3 mol% yttria stabilized zirconia slurry.

After sintering, a method of sol-gel dip coating was involved to make coating layer of mesoporous bioglass (MBGs). The porous zirconia without the coating had high porosities of 60.1% to 63.8%, and most macropores were interconnected with pore sizes of 0.5-0.8mm. The porous zirconia had compressive strengths of 9.07-9.90MPa. Moreover, the average coating thickness was about 7μm. There is no significant change of compressive strength for the porous zirconia with mesoporous biogalss coating. The bone marrow stromal cell (BMSC) proliferation test showed both uncoated and coated zirconia scaffolds have good biocompatibility. The scanning electron microscope (SEM) micrographs and the compositional analysis graphs demonstrated that after testing in the simulated body fluid (SBF) for 7 days, the apatite formation occurred on the coating surface. Thus, porous zirconia-based ceramics were modified with bioactive coating of mesoporous bioglass for potential biomedical applications.

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ID Code: 42491
Item Type: Conference Paper
Refereed: Yes
Keywords: Scaffold, Porous Structure, Mesoporous Bioglass, Yttria-stabilized Zirconia (YSZ), Compressive Strength
ISBN: 9780980582741
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Copyright Owner: Copyright 2011 LIN, F., YAN, C., & ADAM, C.
Copyright Statement: This publication contains conference proceedings. Reproduction, but not modification, is permissible without the authors‘ consent provided that the authors‘ work is referenced appropriately. No modification of the contents of
this publication is allowed. The Organising Committee and Queensland University of Technology are not responsible for the statements or opinions expressed in this publication. Any statements or views expressed in the papers contained in these Proceedings are those of the author(s). Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
Deposited On: 07 Jul 2011 23:20
Last Modified: 18 Jul 2017 16:02

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