Preliminary characterisation of the surface of cartilage following exposure to saturated and unsaturated synthetic lipids
Yusuf, Kenny, Gudimetla, Prasad, Pawlak, Zenon , & Oloyede, Adekunle (2011) Preliminary characterisation of the surface of cartilage following exposure to saturated and unsaturated synthetic lipids. In The First International Postgraduate Conference on Engineering, Designing and Developing the Built Environment for Sustainable Wellbeing, Queensland University of Technology, Brisbane, Qld, pp. 347-351.
Articular cartilage is covered by a microscopic structure known as surface amorphous layer. This surface structure is often the first victim of attack during cartilage degeneration, thereby resulting in a gross impairment in cartilage function such as lubrication and load bearing. We hypothesize that incubation of degraded cartilage in solutions of different species of synthetic surface active phospholipids (saturated and unsaturated species) can remodel this lost surface structure. To test this hypothesis, the structural configuration of the surface of articular cartilage was studied and characterised with the lipid filled surface amorphous layer intact using the AFM. The results were then compared with those obtained following a systematic removal (delipidization) and replacement (relipidization) of this layer. Our results show that the unsaturated surfactant partially restored the lost surface amorphous layer while the saturated surfactant specie settled on the surface due to its poor solubility in aqueous solution.
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|Item Type:||Conference Paper|
|Keywords:||AFM, Articular Cartilage, Surface Amorphous Layer, Lubrication, Load Bearing, Delipidization, Relipidization|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Rehabilitation Engineering (090305)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Past > Schools > School of Engineering Systems
|Copyright Owner:||Copyright 2011 QUT and the authors|
|Copyright Statement:||This publication contains conference proceedings. Reproduction, but not modification, is permissible without the authors' consent provided that the authors' work is referenced appropriately. No modification of the contents of this publication is allowed. The Organising Committee and Queensland University of Technology are not responsible for the statements or opinions expressed in this publication. Any statements or views expressed in the papers contained in these Proceedings are those of the author(s). Mention of trade names or commercial products does not constitute endorsement or recommendation for use.|
|Deposited On:||08 Jul 2011 08:37|
|Last Modified:||27 Jul 2011 22:24|
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