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Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure

Wu , Chengtie, Fan, Wei, Zhu, Yufang , Gelinsky, Michael , Chang, Jiang , Cuniberti, Gianaurelio , Albrecht, Victoria , Friis, Thor, & Xiao, Yin (2011) Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure. Acta Biomaterilia, 7(10), pp. 3563-3572.

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Abstract

Hyperthermia and local drug delivery have been proposed the potential therapeutic approaches for bone defects resulting from malignant bone tumors. Development of bioactive materials with magnetic and drug-delivery properties may potentially meet this target. The aim of this study is to develop a multifunctional mesoporous bioactive glass (MBG) scaffold system for both hyperthermia and local-drug delivery application potentially. For this aim, Iron (Fe) containing MBG (Fe-MBG) scaffolds with hierarchically large pores (300-500 µm) and fingerprint-like mesopores (4.5 nm) have been successfully prepared. The effect of Fe on the mesopore structure, physiochemical, magnetism, drug delivery and biological properties of MBG scaffolds has been systematically investigated. The results showed that the morphology of the mesopore varied from straight channels to curved fingerprint-like channels after incorporated parts of Fe into MBG scaffolds. The magnetism magnitude of MBG scaffolds can be tailored by controlling Fe contents. Furthermore, the incorporating of Fe into mesoporous MBG glass scaffolds enhanced the mitochondrial activity and bone-relative gene (ALP and OCN) expression of human bone marrow mesenchymal stem cells (BMSCs) on the scaffolds. The obtained Fe-MBG scaffolds also possessed high specific surface areas and sustained drug delivery. Therefore, Fe-MBG scaffolds are magnetic, degradable and bioactive. The multifunction of Fe-MBG scaffolds indicates that there is a great potential for Fe-MBG scaffolds to be used for the therapy and regeneration of large-bone defects caused by malignant bone tumors through the combination of hyperthermia, local drug delivery and their osteoconductivity.

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28 citations in Web of Science®

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ID Code: 42571
Item Type: Journal Article
Additional Information: Elsevier first online publication
Keywords: Magnetic scaffolds, Mesoporous bioactive glasses, Drug delivery, Hyperthermia
DOI: 10.1016/j.actbio.2011.06.028
ISSN: 1742-7061
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2011 Elsevier
Deposited On: 14 Jul 2011 10:27
Last Modified: 14 Apr 2012 13:00

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