The Streptozotocin-Diabetic Rat as a Model of the Chronic Complications of Human Diabetes

Wei, Michael, Ong, Leslie, Smith, Maree T., Ross, Fraser B., Schmid, Katrina L., Hoey, Andrew J., Burstow, Darryl J., & Brown, Lindsay C. (2003) The Streptozotocin-Diabetic Rat as a Model of the Chronic Complications of Human Diabetes. Heart, Lung and Circulation, 12(1), pp. 44-50.

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Abstract

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat. Methods: This project assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post STZ administration in rats. Results: STZ-diabetic rate (n=96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in bodyweight): 52% of untreated STZ-diabetic rats (n=50) survived 24 weeks after STZ administration. STZ-diabetic rats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabetic rats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks. Conclusion: The chronic STZ-diabetic rat mimics many but not all of the chronic complications observed in the diabetic human. The chronic STZ-diabetic rat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans.

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ID Code: 4258
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: l.brown@mailbox.uq.edu.au
Keywords: cataracts, diabetes, echocardiography, electrophysiology, neuropathic pain, retinopathy
DOI: 10.1046/j.1444-2892.2003.00160.x
ISSN: 1443-9506
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Elsevier
Deposited On: 14 Jun 2006 00:00
Last Modified: 29 Feb 2012 13:01

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