The autonomic control of accommodation and implications for human myopia development: a review

Chen, Jennifer C., Schmid, Katrina L., & Brown, Brian (2003) The autonomic control of accommodation and implications for human myopia development: a review. Ophthalmic and Physiological Optics, 23(5), pp. 401-422.

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Prolonged nearwork has long been associated with myopia development, however, there is no well described linking mechanism. One theory suggests that if accommodation accuracy during nearwork is not maintained, the defocused retinal image leads to myopia development. Here we review the findings of research aimed at determining whether the autonomic inputs to the ciliary smooth muscle are involved in this type of environmental myopia. We examine whether an autonomic imbalance could be a precursor to axial elongation and the resulting myopia. Accommodation responses, such as tonic accommodation and nearwork-induced accommodative adaptation, as a function of refractive error, are described in relation to an autonomic imbalance model. The collective results of this research point to anomalous accommodation responses, possibly as a result of underlying anomalous autonomic input to the ciliary muscle, being involved in myopia development and progression.

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38 citations in Web of Science®
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ID Code: 4267
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see link) or contact the author. Author contact details:
Keywords: Accommodation, Ocular/, physiology, Autonomic Nervous System/, physiopathology, Myopia/, etiology, Administration, Topical, Autonomic Agents/administration & dosage, Ciliary Body/innervation, Ciliary Body/physiopathology, Humans, Muscle, Smooth/innervation, Muscle, Smooth/physiopathology, Myopia/physiopathology, Myopia/prevention & control, Refractive Errors/physiopathology, Research Support, Non, U, S, Gov't, Sympathetic Nervous System/physiopathology
DOI: 10.1046/j.1475-1313.2003.00135.x
ISSN: 0275-5408
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Blackwell Publishing
Deposited On: 14 Jun 2006 00:00
Last Modified: 29 Feb 2012 13:00

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