The effect of a beta-adrenoceptor antagonist on accommodative adaptation in Hong Kong children
Chen, Jennifer C., Schmid, Katrina L., Brown, Brian, & Edwards, Marion H. (2005) The effect of a beta-adrenoceptor antagonist on accommodative adaptation in Hong Kong children. Current Eye Research, 30(3), pp. 179-188.
PURPOSE: Increased susceptibility to nearwork-induced accommodative adaptation has been suggested as a risk factor for myopia development. We investigated whether accommodative adaptation may explain in part the high prevalence of myopia in Hong Kong children and examined the effect of beta-antagonism with topical timolol maleate on accommodative adaptation.Methods: Thirty children (10 emmetropes and 20 myopes) aged between 8 and 12 years were recruited. Tonic accommodation was measured before and after 5 min of video game-playing using an open-field Shin-Nippon autorefractor. Measurements were repeated 30 min after timolol instillation. RESULTS: Children with progressing myopia demonstrated accommodative adaptation following the near task, whereas stable myopes showed counter-adaptive, hyperopic accommodative changes. Timolol increased the magnitude of accommodative adaptation in the stable myopes but had little effect on responses of the progressing myopes or emmetropes. CONCLUSIONS: Neuropharmacological modulation of the accommodative system may have a possible etiological role in the progression of myopia.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: firstname.lastname@example.org|
|Keywords:||Accommodation, Ocular/, drug effects, Adaptation, Ocular/, drug effects, Adrenergic beta, Antagonists/, pharmacology, Timolol/, pharmacology, Child, Female, Hong Kong/ethnology, Humans, Male, Myopia/ethnology, Myopia/physiopathology|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2005 Taylor & Francis|
|Copyright Statement:||First published in Current Eye Research 30(3):pp. 179-188.|
|Deposited On:||22 Jun 2006 00:00|
|Last Modified:||29 Feb 2012 13:15|
Repository Staff Only: item control page