Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma

Zhao, Hong, Dong, Ying, Quan, Jingjing, Smith, Robert A., Lam, Alfred, Weinstein, Stephen, Clements, Judith, Johnson, Newell, & Gao, Jin (2011) Correlation of the expression of human kallikrein-related peptidases 4 and 7 with the prognosis in oral squamous cell carcinoma. Head and Neck, 33(4), pp. 566-572.

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Background Very few articles have been written about the expression of kallikreins (KLK4 and KLK7) in oral cancers. Therefore, the purpose of this study was to examine and report on their prognostic potential.

Methods Eighty archival blocks of primary oral cancers were sectioned and stained for KLK4 and KLK7 by immunohistochemistry. The percentage and the intensity of malignant keratinocyte staining were correlated with patient survival using Cox regression analysis.

Results Both kallikreins were expressed strongly in the majority of tumor cells in 68 of 80 cases: these were mostly moderately or poorly differentiated neoplasms. Staining was particularly intense at the infiltrating front. Patients with intense staining had significantly shorter overall survival (p < .05).

Conclusion This is the first observation on the patient survival influenced by kallikrein expression in oral carcinoma. The findings are consistent with those for carcinomas at other sites, in particular the prostate and ovary. KLK4 and/or KLK7 immunohistochemistry seems to have diagnostic and prognostic potential in this disease.

Impact and interest:

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ID Code: 42879
Item Type: Journal Article
Refereed: Yes
Keywords: oral squamous cell carcinoma, kallikrein serine proteases, immunohistochemistry, prognosis
DOI: 10.1002/hed.21496
ISSN: 1043-3074
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Wiley Periodicals, Inc.
Deposited On: 13 Jul 2011 13:07
Last Modified: 04 Aug 2014 01:57

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