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Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression

Hugo, Honor, Ackland, Leigh, Blick, Tony, Lawrence, Mitchell, Clements, Judith, Williams, Elizabeth, & Thompson, Erik W. (2007) Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression. Journal of Cellular Physiology, 213(2), pp. 374-383.

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Abstract

Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life mirror those of one of the most common cause of death—metastatic cancer. Epithelial to mesenchymal transition (EMT) is an important change in cell phenotype which allows the escape of epithelial cells from the structural constraints imposed by tissue architecture, and was first recognized by Elizabeth Hay in the early to mid 1980's to be a central process in early embryonic morphogenesis. Reversals of these changes, termed mesenchymal to epithelial transitions (METs), also occur and are important in tissue construction in normal development. Over the last decade, evidence has mounted for EMT as the means through which solid tissue epithelial cancers invade and metastasize. However, demonstrating this potentially rapid and transient process in vivo has proven difficult and data connecting the relevance of this process to tumor progression is still somewhat limited and controversial. Evidence for an important role of MET in the development of clinically overt metastases is starting to accumulate, and model systems have been developed. This review details recent advances in the knowledge of EMT as it occurs in breast development and carcinoma and prostate cancer progression, and highlights the role that MET plays in cancer metastasis. Finally, perspectives from a clinical and translational viewpoint are discussed

Impact and interest:

457 citations in Scopus
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416 citations in Web of Science®

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ID Code: 42926
Item Type: Journal Article
Keywords: E-cadherin, Epithelial-Mesenchymal Transition, Prostate Cancer, Breast Cancer
DOI: 10.1002/jcp.21223
ISSN: 0021-9541
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 13 Jul 2011 23:08
Last Modified: 02 Jun 2014 15:40

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