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Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells

Whitbread, Astrid, Veveris-Lowe, Tara, Dong, Ying, Tan, Olivia, Gardiner, Robert, Samaratunga, Hema, Nicol, David, & Clements, Judith (2010) Expression of PSA-RP2, an alternatively spliced variant from the PSA gene, is increased in prostate cancer tissues but the protein is not secreted from prostate cancer cells. Biological Chemistry: official scientific journal of the GBM, 391(4), pp. 461-466.

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Abstract

PSA-RP2 is a variant transcript expressed from the PSA gene that is conserved in gorillas, chimpanzees and humans suggesting a particular relevance for this transcript in these primates. We demonstrated by qRT-PCR that PSA-RP2 is upregulated in prostate cancer compared with benign prostatic hyperplasia tissues. The PSA-RP2 protein was not detected in seminal fluid and was cytoplasmically localised but not secreted from LNCaP or transfected PC3 prostate cells, despite secretion from transfected Cos-7 and HEK293 kidney cell lines. PSA-RP2-transfected PC3 cells showed slightly decreased proliferation and increased migration towards PC3-conditioned medium that could suggest a functional role in prostate cancer.

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5 citations in Scopus
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4 citations in Web of Science®

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50 since deposited on 13 Jul 2011
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ID Code: 43107
Item Type: Journal Article
Keywords: alternative splicing, biomarker, kallikrein-related peptidase, prostate-specific antigen (PSA)
DOI: 10.1515/BC.2010.043
ISSN: 1431-6730
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Walter de Gruyter
Copyright Statement: The final publication is available at www.degruyter.com
Deposited On: 13 Jul 2011 23:09
Last Modified: 26 Jul 2013 12:01

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