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Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis

Stockton, Kellie, Mengersen, Kerrie, Paratz, J, Kandiah, D, & Bennell, Kim (2011) Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporosis International, 22(3), pp. 859-871.

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Abstract

Summary
This systematic review demonstrates that vitamin D supplementation does not have a significant effect on muscle strength in vitamin D replete adults. However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency. Introduction
The purpose of this study is to systematically review the evidence on the effect of vitamin D supplementation on muscle strength in adults. Methods
A comprehensive systematic database search was performed. Inclusion criteria included randomised controlled trials (RCTs) involving adult human participants. All forms and doses of vitamin D supplementation with or without calcium supplementation were included compared with placebo or standard care. Outcome measures included evaluation of strength. Outcomes were compared by calculating standardised mean difference (SMD) and 95% confidence intervals. Results
Of 52 identified studies, 17 RCTs involving 5,072 participants met the inclusion criteria. Meta-analysis showed no significant effect of vitamin D supplementation on grip strength (SMD −0.02, 95%CI −0.15,0.11) or proximal lower limb strength (SMD 0.1, 95%CI −0.01,0.22) in adults with 25(OH)D levels >25 nmol/L. Pooled data from two studies in vitamin D deficient participants (25(OH)D <25 nmol/L) demonstrated a large effect of vitamin D supplementation on hip muscle strength (SMD 3.52, 95%CI 2.18, 4.85). Conclusion
Based on studies included in this systematic review, vitamin D supplementation does not have a significant effect on muscle strength in adults with baseline 25(OH)D >25 nmol/L. However, a limited number of studies demonstrate an increase in proximal muscle strength in adults with vitamin D deficiency.

Keywords Muscle – Muscle fibre – Strength – Vitamin D

Impact and interest:

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60 citations in Web of Science®

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ID Code: 43180
Item Type: Journal Article
Keywords: Muscle, Muscle fibre, Strength, Vitamin D
DOI: 10.1007/s00198-010-1407-y
ISSN: 0937-941X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Mathematical Sciences
Deposited On: 13 Jul 2011 23:10
Last Modified: 03 Dec 2012 12:06

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