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Replication of the Frank-Starling response in a Mock Circulation loop

Gregory, Shaun, Stevens, Michael, Timms, Daniel L., & Pearcy, Mark J. (2011) Replication of the Frank-Starling response in a Mock Circulation loop. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2011), 30 August - 3 September 2011, Boston Marriott Copley Place Hotel, Boston, MA. (In Press)

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Abstract

Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL’s pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.

Impact and interest:

2 citations in Scopus
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1 citations in Web of Science®

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202 since deposited on 20 Jul 2011
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ID Code: 43403
Item Type: Conference Paper
Keywords: mock circulation loop, ventricular assist device, Frank Starling response
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Medical Devices (090304)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2011 [Please consult the authors]
Deposited On: 21 Jul 2011 08:31
Last Modified: 13 Aug 2011 12:53

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