Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males
Pecheniuk, Natalie Maria, Deguchi, Hiroshi, Elias, Darlene, Xu, Xiao, & Griffin, John (2006) Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males. Journal Of Thrombosis And Haemostasis, 4(9), pp. 2080-2082.
Although numerous genetic and acquired factors are appreciated as risk factors for venous thromboembolism (VTE) [1,2], only recently have male gender [3,4], dyslipoproteinemia , and silent atherosclerotic vascular disease  been linked to VTE. We recently found that high-density lipoprotein (HDL) deficiency is a key feature of a pattern of dyslipoproteinemia that is associated with VTE in males, and we found that the common TaqI B1 variation in the cholesteryl ester transfer protein (CETP) gene is significantly linked to VTE . However, the TaqI B1/B2 single nucleotide polymorphism (SNP) itself is unlikely to affect directly CETP activity, but it is linked to nonsynonymous CETP SNPs Ala373Pro and Arg451Gln [7–9]. Here, we demonstrate that these two CETP variations are associated with VTE and low plasma HDL levels in males.
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|Item Type:||Journal Article|
|Keywords:||venous thrombosis, cholesteryl ester transfer protein|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CARDIOVASCULAR MEDICINE AND HAEMATOLOGY (110200) > Cardiovascular Medicine and Haematology not elsewhere classified (110299)|
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Medical Genetics (excl. Cancer Genetics) (110311)
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Blackwell Publishing|
|Deposited On:||22 Jul 2011 17:43|
|Last Modified:||24 Jul 2011 02:31|
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