High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men
Deguchi, H., Pecheniuk, N. M., Elias, D. J., Averell, P. M., & Griffin, J. H. (2005) High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men. Circulation, 112(6), pp. 893-899.
Background-Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. Methods and Results-We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matched controls aged <55 years. Venous thrombosis patients had significantly lower levels of HDL particles, large HDL particles, HDL cholesterol, and apolipoprotein AI and significantly higher levels of LDL particles and small LDL particles. The quartile-based odds ratios for decreased HDL particle and apolipoprotein AI levels in patients compared with controls were 6.5 and 6.0 (95% CI, 2.3 to 19 and 2.1 to 17), respectively. Odds ratios for apolipoprotein B/apolipoprotein AI ratio and LDL cholesterol/HDL cholesterol ratio were 6.3 and 2.7 (95% CI, 1.9 to 21 and 1.1 to 6.5), respectively. When polymorphisms in genes for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patients differed significantly from controls in the allelic frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the observed pattern of lower HDL and higher LDL. Conclusions-Venous thrombosis in men aged <55 years old is associated with dyslipoproteinemia involving lower levels of HDL particles, elevated levels of small LDL particles, and an elevated ratio of apolipoprotein B/apolipoprotein AI. This dyslipoproteinemia seems associated with a related cholesteryl ester transfer protein genotype difference. © 2005 American Heart Association, Inc.
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|Item Type:||Journal Article|
|Additional Information:||The full-text of this article is freely available via the journal website - see link above|
|Keywords:||Lipoproteins, Men, Risk factors, Thrombosis, apolipoprotein A1, blood clotting factor 5 Leiden, cholesterol, genomic DNA, high density lipoprotein, high density lipoprotein cholesterol, low density lipoprotein, low density lipoprotein cholesterol, triacylglycerol, adult, article, cholesterol blood level, clinical article, controlled study, disease association, dyslipoproteinemia, family history, human, lipoprotein blood level, male, nuclear magnetic resonance spectroscopy, priority journal, risk factor, thromboembolism, venous thromboembolism, Body Mass Index, California, Case-Control Studies, Dyslipidemias, Humans, Lipoproteins, HDL, Middle Aged, Reference Values, Registries, Venous Thrombosis, OAVJ|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation|
|Copyright Owner:||Lippincott, Williams & Wilkins|
|Deposited On:||22 Jul 2011 07:11|
|Last Modified:||25 Jul 2011 03:53|
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