A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice
Carey, Alison J., Cunningham, Kelly A., Andrew, Dean, Hafner, Louise M., Timms, Peter, & Beagley, Kenneth (2011) A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice. Vaccine.
There are approximately 92 million new chlamydial infections of the genital tract in humans diagnosed each year , costing health care systems billions of dollars in treatment not only of acute infections, but also of associated inflammatory sequelae, such as pelvic inflammatory disease (PID) and ectopic pregnancy . These numbers are increasing at a steady rate  and, due to the asymptomatic nature of infections, the incidence may be underestimated and the costs of treatment therefore higher. Over the previous few decades there has been a large amount of research into the development of an efficacious vaccine against genital tract chlamydial infections . The majority of this research has focused on females, due to the high rate of development of associated diseases, including PID, which can lead to ectopic pregnancy and infertility . In light of the increasing infection rates that have occurred despite the availability of antibiotics, and the asymptomatic nature of chlamydial infections, it is imperative that an efficacious vaccine that protects against infection and associated pathology be developed.
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|Item Type:||Journal Article|
|Keywords:||Chlamydia, Pathology, Timing of Vaccination|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)|
|Divisions:||Past > Schools > Cell & Molecular Biosciences|
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Research Centres > Smart Services CRC
|Copyright Owner:||Copyright © 2011 Elsevier Ltd|
|Deposited On:||15 Aug 2011 07:57|
|Last Modified:||15 Aug 2011 07:57|
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