A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice

Carey, Alison J., Cunningham, Kelly A., Andrew, Dean, Hafner, Louise M., Timms, Peter, & Beagley, Kenneth (2011) A comparison of the effects of a chlamydial vaccine administered during or after a C. muridarum urogenital infection of female mice. Vaccine, 29(38), pp. 6505-6513.

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There are approximately 92 million new chlamydial infections of the genital tract in humans diagnosed each year, costing health care systems billions of dollars in treatment not only of acute infections, but also of associated inflammatory sequelae, such as pelvic inflammatory disease (PID) and ectopic pregnancy. These numbers are increasing at a steady rate and, due to the asymptomatic nature of infections, the incidence may be underestimated and the costs of treatment therefore higher. Over the previous few decades there has been a large amount of research into the development of an efficacious vaccine against genital tract chlamydial infections. The majority of this research has focused on females, due to the high rate of development of associated diseases, including PID, which can lead to ectopic pregnancy and infertility. In light of the increasing infection rates that have occurred despite the availability of antibiotics, and the asymptomatic nature of chlamydial infections, it is imperative that an efficacious vaccine that protects against infection and associated pathology be developed.

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6 citations in Scopus
5 citations in Web of Science®
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ID Code: 43942
Item Type: Journal Article
Refereed: Yes
Keywords: Chlamydia, Pathology, Timing of Vaccination
DOI: 10.1016/j.vaccine.2011.07.012
ISSN: 0264-410X
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Past > Schools > Cell & Molecular Biosciences
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Research Centres > Smart Services CRC
Copyright Owner: Copyright 2011 Elsevier Ltd
Copyright Statement: This is the author’s version of a work that was accepted for publication in Vaccine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Vaccine, [VOL 29, ISSUE 38, (2011)] DOI: 10.1016/j.vaccine.2011.07.012
Deposited On: 14 Aug 2011 21:57
Last Modified: 14 Aug 2013 13:02

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