Oscillatory regulation of Hes1: Discrete stochastic delay modelling and simulation

Barrio, Manuel, Burrage, Kevin, Leier, Andre, & Tian, Tianhai (2006) Oscillatory regulation of Hes1: Discrete stochastic delay modelling and simulation. PLoS Computational Biology, 2(9), pp. 1017-1030.

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Discrete stochastic simulations are a powerful tool for understanding the dynamics of chemical kinetics when there are small-to-moderate numbers of certain molecular species. In this paper we introduce delays into the stochastic simulation algorithm, thus mimicking delays associated with transcription and translation. We then show that this process may well explain more faithfully than continuous deterministic models the observed sustained oscillations in expression levels of hes1 mRNA and Hes1 protein.

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120 citations in Scopus
118 citations in Web of Science®
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ID Code: 44659
Item Type: Journal Article
Refereed: Yes
DOI: 10.1371/journal.pcbi.0020117
ISSN: 1553-734X
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000)
Deposited On: 24 Aug 2011 22:13
Last Modified: 25 Nov 2016 01:09

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