QUT ePrints

Slow flash multifocal electroretinogram in myopia

Chen, Jennifer C., Brown, Brian, & Schmid, Katrina L. (2006) Slow flash multifocal electroretinogram in myopia. Vision Research, 46(18), pp. 2869-2876.

View at publisher

Abstract

Purpose The purpose of this study was to investigate the characteristics of retinal function in myopes using a modified multifocal electroretinogram (mfERG) protocol, the slow flash (sf-mfERG) paradigm, which is thought to primarily reflect responses of ON- and OFF-bipolar cells and emphasize the late response components.

Methods Twenty-eight subjects (10 emmetropes and 18 myopes) underwent mfERG testing using VERIS 5.1.5X. The sf-mfERG stimulus array consisted of 103-scaled hexagons and flickered according to a pseudorandom binary m-sequence (213-1). The stimulation sequence was slowed by inserting three dark frames such that each step in the m-sequence was four frames long (53.3 ms). The amplitude and implicit time of the major sf-mfERG waveform features (N1, P1, and N2) of the first-order kernel were analysed.

Results Myopes had significantly reduced P1 and N2 amplitudes compared to the emmetropes (F1, 25 = 8.818, p = 0.007; F1, 25 = 6.723, p = 0.017). There were no significant differences in N1 amplitude or implicit time between the groups (F1, 25 = 1.506, p = 0.233; F1, 25 = 1.291, p = 0.269).

Conclusions Late response components (P1 and N2) of the first-order sf-mfERG responses were preferentially affected in myopia, suggesting possible reduced ON- and OFF-bipolar cell activity. As bipolar cells form the first synapse of the visual system with the photoreceptors to initiate the ON- and OFF-pathways, future investigations of ON- and OFF-systems in myopia are of interest.

Impact and interest:

8 citations in Scopus
Search Google Scholar™
5 citations in Web of Science®

Citation countsare sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 4467
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Keywords: Myopia, Multifocal electroretinogram, Slow flash mfERG, Refractive error
DOI: 10.1016/j.visres.2006.02.021
ISSN: 0042-6989
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Elsevier
Deposited On: 14 Jun 2006
Last Modified: 29 Feb 2012 23:25

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page