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The CDKN2A (p16) gene and human cancer

Foulkes, William D., Flanders, Tamar Y., Pollock, Pamela M., & Hayward, Nicholas K. (1997) The CDKN2A (p16) gene and human cancer. Molecular Medicine, 3(1), pp. 5-20.

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Abstract

CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome. In this review we tabulate the known mutations in this gene and discuss specific aspects, particularly with respect to germline mutations and cancer predisposition.

Impact and interest:

109 citations in Scopus
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112 citations in Web of Science®

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ID Code: 45811
Item Type: Journal Article
Additional URLs:
Keywords: Carrier Proteins/ genetics, Cyclin-Dependent Kinase Inhibitor p16, Genes, Tumor Suppressor/ genetics, Humans, Mutation, Neoplasms/ genetics
ISSN: 1076-1551
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Past > Schools > Cell & Molecular Biosciences
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1997 The Feinstein Institute for Medical Research
Deposited On: 09 Sep 2011 11:01
Last Modified: 09 Sep 2011 11:01

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