The CDKN2A (p16) gene and human cancer
Foulkes, William D., Flanders, Tamar Y., Pollock, Pamela M., & Hayward, Nicholas K. (1997) The CDKN2A (p16) gene and human cancer. Molecular Medicine, 3(1), pp. 5-20.
CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome. In this review we tabulate the known mutations in this gene and discuss specific aspects, particularly with respect to germline mutations and cancer predisposition.
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||Carrier Proteins/ genetics, Cyclin-Dependent Kinase Inhibitor p16, Genes, Tumor Suppressor/ genetics, Humans, Mutation, Neoplasms/ genetics|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)|
|Divisions:||Past > Schools > Cell & Molecular Biosciences|
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1997 The Feinstein Institute for Medical Research|
|Deposited On:||09 Sep 2011 11:01|
|Last Modified:||09 Sep 2011 11:01|
Repository Staff Only: item control page