Molecular classification of cutaneous malignant melanoma by gene expression profiling
Bittner, M. , Meltzer, P. , Chen, Y. , Jiang, Y. , Seftor, E. , Hendrix, M. , Radmacher, M. , Simon, R. , Yakhini, Z. , Ben-Dor, A. , Sampas, N. , Dougherty, E. , Wang, E. , Marincola, F. , Gooden, C. , Lueders, J. , Glatfelter, A. , Pollock, P.M., Carpten, J. , Gillanders, E. , Leja, D. , Dietrich, K. , Beaudry, C. , Berens, M. , Alberts, D. , & Sondak, V. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature, 406(6795), pp. 536-540.
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The most common human cancers are malignant neoplasms of the skin. Incidence of cutaneous melanoma is rising especially steeply, with minimal progress in non-surgical treatment of advanced disease. Despite significant effort to identify independent predictors of melanoma outcome, no accepted histopathological, molecular or immunohistochemical marker defines subsets of this neoplasm. Accordingly, though melanoma is thought to present with different 'taxonomic' forms, these are considered part of a continuous spectrum rather than discrete entities. Here we report the discovery of a subset of melanomas identified by mathematical analysis of gene expression in a series of samples. Remarkably, many genes underlying the classification of this subset are differentially regulated in invasive melanomas that form primitive tubular networks in vitro, a feature of some highly aggressive metastatic melanomas. Global transcript analysis can identify unrecognized subtypes of cutaneous melanoma and predict experimentally verifiable phenotypic characteristics that may be of importance to disease progression.
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|Item Type:||Journal Article|
|Keywords:||Adult, Cluster Analysis, Disease Progression, Female, Gene Expression Profiling, Humans, Male, Melanoma/ classification/genetics, Middle Aged, Neoplasm Invasiveness, Prognosis, RNA, Messenger/metabolism, Skin Neoplasms/ classification/genetics, Tumor Cells, Cultured, Uveal Neoplasms/classification/genetics|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)|
|Divisions:||Past > Schools > Cell & Molecular Biosciences|
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||09 Sep 2011 14:21|
|Last Modified:||09 Sep 2011 14:21|
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