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A genome-based strategy uncovers frequent BRAF mutations in melanoma

Pollock, Pamela M. & Meltzer, Paul S. (2002) A genome-based strategy uncovers frequent BRAF mutations in melanoma. Cancer Cell, 2(1), pp. 5-7.

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Abstract

Using a genome-scanning approach to search for oncogenes, a recent report identifies somatic mutations in the signaling gene BRAF that are particularly prevalent in melanoma.

Impact and interest:

89 citations in Scopus
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76 citations in Web of Science®

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ID Code: 45820
Item Type: Journal Article
Additional URLs:
Keywords: Cell Transformation, Neoplastic, Humans, Melanoma/enzymology/ genetics/metabolism/pathology, Mitogen-Activated Protein Kinases/metabolism, Models, Biological, Mutation, Point Mutation/genetics, Protein Structure, Tertiary, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-raf/chemistry/ genetics/metabolism, Signal Transduction, Tumor Cells, Cultured, ras Proteins/metabolism
DOI: 10.1016/S1535-6108(02)00089-2
ISSN: 1535-6108
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Past > Schools > Cell & Molecular Biosciences
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 09 Sep 2011 14:33
Last Modified: 09 Sep 2011 14:33

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