High frequency of BRAF mutations in nevi
Pollock, P.M., Harper, U.L. , Hansen, K.S. , Yudt, L.M. , Stark, M. , Robbins, C.M. , Moses, T.Y. , Hostetter, G. , Wagner, U. , Kakareka, J. , Salem, G. , Pohida, T. , Heenan, P. , Duray, P. , Kallioniemi, O. , Hayward, N.K. , Trent, J.M. , & Meltzer, P.S. (2003) High frequency of BRAF mutations in nevi. Nature Genetics, 33(1), pp. 19-20.
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis.
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|Item Type:||Journal Article|
|Keywords:||Cell Transformation, Neoplastic/genetics, DNA Mutational Analysis, Gene Frequency, Genetic Predisposition to Disease, Humans, Melanoma/ genetics/pathology, Mutation, Missense/ genetics, Nevus/ genetics/pathology, Oncogene Proteins v-raf/chemistry/ genetics, Polymerase Chain Reaction, Signal Transduction|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)|
|Divisions:||Past > Schools > Cell & Molecular Biosciences|
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||09 Sep 2011 14:52|
|Last Modified:||09 Sep 2011 14:52|
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