Exploring the parameter space of a rabbit ventricular action potential model to investigate the effect of variation on action potential and calcium transients

Gemmell, Philip, Burrage, Kevin, Rodriguez, Blanca, & Quinn, T. Alexander (2010) Exploring the parameter space of a rabbit ventricular action potential model to investigate the effect of variation on action potential and calcium transients. In 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), 31 August - 4 September 2010, Buenos Aires Sheraton Hotel, Buenos Aires.

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Computational models for cardiomyocyte action potentials (AP) often make use of a large parameter set. This parameter set can contain some elements that are fitted to experimental data independently of any other element, some elements that are derived concurrently with other elements to match experimental data, and some elements that are derived purely from phenomenological fitting to produce the desired AP output. Furthermore, models can make use of several different data sets, not always derived for the same conditions or even the same species. It is consequently uncertain whether the parameter set for a given model is physiologically accurate. Furthermore, it is only recently that the possibility of degeneracy in parameter values in producing a given simulation output has started to be addressed. In this study, we examine the effects of varying two parameters (the L-type calcium current (I(CaL)) and the delayed rectifier potassium current (I(Ks))) in a computational model of a rabbit ventricular cardiomyocyte AP on both the membrane potential (V(m)) and calcium (Ca(2+)) transient. It will subsequently be determined if there is degeneracy in this model to these parameter values, which will have important implications on the stability of these models to cell-to-cell parameter variation, and also whether the current methodology for generating parameter values is flawed. The accuracy of AP duration (APD) as an indicator of AP shape will also be assessed.

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1 citations in Web of Science®
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ID Code: 45871
Item Type: Conference Paper
Refereed: Yes
Keywords: Biomembranes , Calcium , Computational modeling , Mathematical model , Rabbits , Shape , Steady-state
DOI: 10.1109/IEMBS.2010.5626617
ISBN: 9781424441235
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Mathematical Sciences
Deposited On: 15 Sep 2011 04:35
Last Modified: 15 Sep 2011 04:35

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