Modeling intrinsic noise and delays in chemical kinetics of coupled autoregulated oscillating cells

Leier, Andre, Marquez-Lago, Tatiana, Burrage, Kevin, & Burrage, Pamela (2008) Modeling intrinsic noise and delays in chemical kinetics of coupled autoregulated oscillating cells. International Journal for Multiscale Computational Engineering, 6(1), pp. 77-86.

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Delays are an important feature in temporal models of genetic regulation due to slow biochemical processes, such as transcription and translation. In this paper, we show how to model intrinsic noise effects in a delayed setting by either using a delay stochastic simulation algorithm (DSSA) or, for larger and more complex systems, a generalized Binomial τ-leap method (Bτ-DSSA). As a particular application, we apply these ideas to modeling somite segmentation in zebra fish across a number of cells in which two linked oscillatory genes (her1 and her7) are synchronized via Notch signaling between the cells.

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2 citations in Scopus
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1 citations in Web of Science®

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ID Code: 45990
Item Type: Journal Article
Refereed: Yes
Keywords: Chemical kinetics, Oscillating cells
DOI: 10.1615/IntJMultCompEng.v6.i1.70
ISSN: 1940-4352
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > Schools > Computer Science
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Mathematical Sciences
Deposited On: 15 Sep 2011 04:13
Last Modified: 25 Oct 2016 23:41

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