Stochastic analysis of the VEGF receptor response curve

Macnamara, Shev, Burrage, Kevin, & Sidje, Roger B. (2007) Stochastic analysis of the VEGF receptor response curve. In Pham, Tuan D. & Zhou, Xiaobo (Eds.) Computational Models For Life Sciences (CMLS '07): Proceedings of International Symposium on Computational Models for Life Sciences, Springer, Australia, Queensland, pp. 238-247.

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Recently, an analysis of the response curve of the vascular endothelial growth factor (VEGF) receptor and its application to cancer therapy was described in [T. Alarcón, and K. Page, J. R. Soc. Lond. Interface 4, 283–304 (2007)]. The analysis is significantly extended here by demonstrating that an alternative computational strategy, namely the Krylov FSP algorithm for the direct solution of the chemical master equation, is feasible for the study of the receptor model. The new method allows us to further investigate the hypothesis of symmetry in the stochastic fluctuations of the response. Also, by augmenting the original model with a single reversible reaction we formulate a plausible mechanism capable of realizing a bimodal response, which is reported experimentally but which is not exhibited by the original model. The significance of these findings for mechanisms of tumour resistance to antiangiogenic therapy is discussed.

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ID Code: 46025
Item Type: Conference Paper
Refereed: Yes
Keywords: stochastic analysis , VEGF receptor response curve
ISBN: 978-0-7354-0466-3
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > NUMERICAL AND COMPUTATIONAL MATHEMATICS (010300)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Systems Biology (060114)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Mathematical Sciences
Deposited On: 15 Sep 2011 23:37
Last Modified: 15 Sep 2011 23:37

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