Evolving noisy oscillatory dynamics in genetic regulatory networks

Leier, Andre, Kuo, P. Dwight, Banzhaf, Wolfgang, & Burrage, Kevin (2006) Evolving noisy oscillatory dynamics in genetic regulatory networks. In Collet, Pierre, Tomassini, Marco, Ebner, Marc, Gustafson, Steven, & Ekart, Aniko (Eds.) Lecture Notes in Computer Science : Genetic Programming, Springer, Budapest, pp. 290-299.

View at publisher


We introduce a genetic programming (GP) approach for evolving genetic networks that demonstrate desired dynamics when simulated as a discrete stochastic process. Our representation of genetic networks is based on a biochemical reaction model including key elements such as transcription, translation and post-translational modifications. The stochastic, reaction-based GP system is similar but not identical with algorithmic chemistries. We evolved genetic networks with noisy oscillatory dynamics. The results show the practicality of evolving particular dynamics in gene regulatory networks when modelled with intrinsic noise.

Impact and interest:

12 citations in Scopus
Search Google Scholar™
13 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 46032
Item Type: Conference Paper
Refereed: Yes
Keywords: Computer Science, Theory & Methods, Stochastic Simulation, Escherichia-coli, Expression, Evolution, Cells
DOI: 10.1007/11729976_26
ISBN: 9783540331438
ISSN: 0302-9743
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Mathematical Sciences
Deposited On: 18 Sep 2011 22:23
Last Modified: 25 Oct 2016 23:41

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page