A software tool for simulating spatial separation and kinetics in biological membranes

Nicolau, Jr, Dan V. & Burrage, Kevin (2005) A software tool for simulating spatial separation and kinetics in biological membranes. In Nicolau, Dan V. (Ed.) Biomedical Applications of Micro- and Nanoengineering II, Brisbane, pp. 85-94.

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Self-segregation and compartimentalisation are observed experimentally to occur spontaneously on live membranes as well as reconstructed model membranes. It is believed that many of these processes are caused or supported by anomalous diffusive behaviours of biomolecules on membranes due to the complex and heterogeneous nature of these environments. These phenomena are on the one hand of great interest in biology, since they may be an important way for biological systems to selectively localize receptors, regulate signaling or modulate kinetics; and on the other, they provide an inspiration for engineering designs that mimick natural systems. We present an interactive software package we are developing for the purpose of simulating such processes numerically using a fundamental Monte Carlo approach. This program includes the ability to simulate kinetics and mass transport in the presence of either mobile or immobile obstacles and other relevant structures such as liquid-ordered lipid microdomains. We also present preliminary simulation results regarding the selective spatial localization and chemical kinetics modulating power of immobile obstacles on the membrane, obtained using the program.

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ID Code: 46154
Item Type: Conference Paper
Refereed: Yes
DOI: 10.1117/12.585052
ISBN: 9780819456113
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2005 SPIE
Deposited On: 28 Sep 2011 01:44
Last Modified: 14 Jul 2017 11:01

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