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Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes

Walmsley, John, Mirams, Gary, Bahoshy, Maya, Bollensdorff, Christian, Rodriguez, Blanca, & Burrage, Kevin (2010) Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes. In 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2010), 31 August - 4 September 2010, Buenos Aires Sheraton Hotel, Argentina.

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Abstract

Experimental action potential (AP) recordings in isolated ventricular myoctes display significant temporal beat-to-beat variability in morphology and duration. Furthermore, significant cell-to-cell differences in AP also exist even for isolated cells originating from the same region of the same heart. However, current mathematical models of ventricular AP fail to replicate the temporal and cell-to-cell variability in AP observed experimentally. In this study, we propose a novel mathematical framework for the development of phenomenological AP models capable of capturing cell-to-cell and temporal variabilty in cardiac APs. A novel stochastic phenomenological model of the AP is developed, based on the deterministic Bueno-Orovio/Fentonmodel. Experimental recordings of AP are fit to the model to produce AP models of individual cells from the apex and the base of the guinea-pig ventricles. Our results show that the phenomenological model is able to capture the considerable differences in AP recorded from isolated cells originating from the location. We demonstrate the closeness of fit to the available experimental data which may be achieved using a phenomenological model, and also demonstrate the ability of the stochastic form of the model to capture the observed beat-to-beat variablity in action potential duration.

Impact and interest:

6 citations in Scopus
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3 citations in Web of Science®

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ID Code: 46188
Item Type: Conference Paper
Keywords: Bueno-Orovio/Fenton model, Action potential duration, Action potential recordings, Beat-to-beat variability , Cardiac cation potentials, Cell-to-cell variability, Isolated guinea pig ventricular myocytes, Phenomenological modeling, Temporal variability, Bioelectric potentials, Cardiology, Cellular biophysics, Physiological models
DOI: 10.1109/IEMBS.2010.5626858
ISSN: 1557-170X
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2010 IEEE
Deposited On: 28 Sep 2011 11:49
Last Modified: 28 Sep 2011 11:49

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