Corneal markers of diabetic neuropathy

Pritchard, Nicola, Edwards, Katie P., Shahidi, Ayda M., Sampson, Geoff P., Russell, Anthony W., Malik, Rayaz A., & Efron, Nathan (2011) Corneal markers of diabetic neuropathy. Ocular Surface, 9(1), pp. 17-28.

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Diabetic neuropathy is a significant clinical problem that currently has no effective therapy, and in advanced cases, leads to foot ulceration and lower limb amputation. The accurate detection, characterization and quantification of this condition are important in order to define at-risk patients, anticipate deterioration, monitor progression, and assess new therapies This review evaluates novel corneal methods of assessing diabetic neuropathy. Two new non-invasive corneal markers have emerged, and in cross-sectional studies have demonstrated their ability to stratify the severity of this disease. Corneal confocal microscopy allows quantification of corneal nerve parameters and non-contact corneal esthesiometry, the functional correlate of corneal structure, assesses the sensitivity of the cornea. Both these techniques are quick to perform, produce little or no discomfort for the patient, and are suitable for clinical settings. Each has advantages and disadvantages over traditional techniques for assessing diabetic neuropathy. Application of these new corneal markers for longitudinal evaluation of diabetic neuropathy has the potential to reduce dependence on more invasive, costly, and time-consuming assessments, such as skin biopsy.

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25 citations in Scopus
26 citations in Web of Science®
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ID Code: 46514
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: corneal confocal microscopy, corneal markers, corneal nerves, corneal sensitivity, diabetic neuropathy, noncontact corneal esthesiometry
ISSN: 1542-0124
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2011 Ethics communication Inc.
Deposited On: 17 Oct 2011 23:53
Last Modified: 19 Oct 2011 09:47

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