A sequential Monte Carlo approach to design for population pharmacokinetics studies
McGree, J.M., Drovandi, C.C., & Pettitt, A.N. (2012) A sequential Monte Carlo approach to design for population pharmacokinetics studies. Journal of Pharmacokinetics and Pharmacodynamics, 39(5), pp. 519-526.
Here we present a sequential Monte Carlo approach that can be used to find optimal designs. Our focus is on the design of phase III clinical trials where the derivation of sampling windows is required, along with the optimal sampling schedule. The search is conducted via a particle filter which traverses a sequence of target distributions artificially constructed via an annealed utility. The algorithm derives a catalogue of highly efficient designs which, not only contain the optimal, but can also be used to derive sampling windows. We demonstrate our approach by designing a hypothetical phase III clinical trial.
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|Item Type:||Journal Article|
|Keywords:||Optimal design, Particle filter, Sampling windows, Sequential Monte Carlo, Utility|
|Subjects:||Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > STATISTICS (010400)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2012 Springer|
|Copyright Statement:||The original publication is available at SpringerLink http://www.springerlink.com|
|Deposited On:||20 Oct 2011 00:33|
|Last Modified:||04 Jul 2015 12:40|
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