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Subjective and objective measures of corneal staining related to multipurpose care systems

Pritchard, Nicola, Young, Graeme, Coleman, Sarah, & Hunt, Chris (2003) Subjective and objective measures of corneal staining related to multipurpose care systems. Contact Lens and Anterior Eye, 26(1), pp. 3-9.

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Abstract

An objective, digital-imaging method of measuring corneal staining was evaluated in 24 subjects wearing soft contact lenses. The method was used to compare the clinical performance of common multipurpose care systems (MPS) for soft contact lens care. Subjects used three different MPS, one containing polyquaternium-1 (PQ) and two containing polyhexanide (PX1 and PX2), for 2 weeks in a randomised, single-masked (investigator) crossover study. Corneal staining induced with the three MPS was analysed using an image-processing program (ImageTool, UTHSCSA Version 2, University of Texas, USA). Conjunctival hyperaemia and papillae were also evaluated. The intraclass correlation coefficient was similar with image analysis to that of investigator grading (0.876, 0.879, respectively). Significant differences in staining response were detected using the objective method. There was significantly less staining area with polyquaternium-1 (PQ) than polyhexanide (PQ: 0.12 mm2, PX2: 0.91 mm2). Inferior palpebral papillae were significantly greater with PX2 than with PQ (1.0, 0.7 (0–4), respectively). The technique was shown to be an effective method of evaluating different corneal staining responses. Bilateral corneal staining in three or more quadrants is useful in the diagnosis of MPS-related staining.

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ID Code: 4672
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: (n.pritchard@qut.edu.au)
Keywords: Corneal staining, Multipurpose solution, Image analysis, Polyquaternium, 1, Polyhexanide
DOI: 10.1016/S1367-0484(02)00083-8
ISSN: 1367-0484
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Elsevier
Deposited On: 07 Jul 2006
Last Modified: 29 Feb 2012 23:59

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