A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics
Murphy, Kelly E., Hall, Cameron L., Maini, Philip K., McCue, Scott W., & McElwain, Sean (2012) A fibrocontractive mechanochemical model of dermal wound closure incorporating realistic growth factor kinetics. Bulletin of Mathematical Biology, 74(5), pp. 1143-1170.
Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing. Recent experimental evidence indicates that the transformation from fibroblasts to myofibroblasts involves two distinct processes: the cells are stimulated to change phenotype by the combined actions of transforming growth factor β (TGFβ) and mechanical tension. This observation indicates a need for a detailed exploration of the effect of the strong interactions between the mechanical changes and growth factors in dermal wound healing. We review the experimental findings in detail and develop a model of dermal wound healing that incorporates these phenomena. Our model includes the interactions between TGFβ and collagenase, providing a more biologically realistic form for the growth factor kinetics than those included in previous mechanochemical descriptions. A comparison is made between the model predictions and experimental data on human dermal wound healing and all the essential features are well matched.
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|Item Type:||Journal Article|
|Keywords:||mathematical biology, wound healing, mechanochemical model, fibroblasts, myofibroblasts, TGF beta, collagenase|
|Subjects:||Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)|
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Dermatology (110304)
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
|Copyright Owner:||Copyright 2012 Society for Mathematical Biology|
|Copyright Statement:||The original publication is available at SpringerLink http://www.springerlink.com|
|Deposited On:||17 Jan 2012 08:37|
|Last Modified:||18 Apr 2012 20:14|
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