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Clinical strategies for the alleviation of contractures from a predictive mathematical model of dermal repair

Murphy, Kelly E., McCue, Scott W., & McElwain, Sean (2012) Clinical strategies for the alleviation of contractures from a predictive mathematical model of dermal repair. Wound Repair and Regeneration, 20(2), pp. 194-202.

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Abstract

Hypertrophic scars arise when there is an overproduction of collagen during wound healing. These are often associated with poor regulation of the rate of programmed cell death(apoptosis) of the cells synthesizing the collagen or by an exuberant inflammatory response that prolongs collagen production and increases wound contraction. Severe contractures that occur, for example, after a deep burn can cause loss of function especially if the wound is over a joint such as the elbow or knee. Recently, we have developed a morphoelastic mathematical model for dermal repair that incorporates the chemical, cellular and mechanical aspects of dermal wound healing. Using this model, we examine pathological scarring in dermal repair by first assuming a smaller than usual apoptotic rate for myofibroblasts, and then considering a prolonged inflammatory response, in an attempt to determine a possible optimal intervention strategy to promote normal repair, or terminate the fibrotic scarring response. Our model predicts that in both cases it is best to apply the intervention strategy early in the wound healing response. Further, the earlier an intervention is made, the less aggressive the intervention required. Finally, if intervention is conducted at a late time during healing, a significant intervention is required; however, there is a threshold concentration of the drug or therapy applied, above which minimal further improvement to wound repair is obtained.

Impact and interest:

3 citations in Scopus
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2 citations in Web of Science®

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ID Code: 47834
Item Type: Journal Article
Additional URLs:
Keywords: mathematical modelling, wound healing, myofibroblasts, apoptosis, inflammation, mechanochemical model, morphoelasticity
DOI: 10.1111/j.1524-475X.2012.00775.x
ISSN: 1067-1927
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Dermatology (110304)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2012 the Wound Healing Society
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 20 Dec 2011 23:05
Last Modified: 16 Apr 2013 10:51

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