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Polycaprolactone-based scaffold plus rhBMP-2 in a sheep thoracic spine fusion model

Yong, Mostyn, Melchels, Ferry P.W., Vaquette, Cedryck, Hutmacher, Dietmar, Adam, Clayton J., Domingos, Marco , & Bartolo, Paulo J. (2012) Polycaprolactone-based scaffold plus rhBMP-2 in a sheep thoracic spine fusion model. In Bartolo, Paulo J. (Ed.) Innovative Developments in Virtual and Physical Prototyping: Proceedings of the 5th International Conference on Advanced Research in Virtual and Rapid Prototyping, CRC Press/Balkema, Leiria, Portugal, pp. 89-92.

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Abstract

We report the application of a novel scaffold design in a sheep thoracic spine model for spine deformity correction. The combination of the calcium-phosphate coated polycaprolactone scaffolds with recombinant human bone morphogenic protein-2 (rhBMP-2) are intended as a future bone graft substitute in ensuring the stability of bony intervertebral fusion. A solid free-form fabrication process based on melt extrusion has been utilized in the manufacturing of these scaffolds. To date there are no studies examining the use of such biodegradable implants in a sheep thoracic spine model. The success of anterior scoliosis surgery in humans depends on achieving a solid bony fusion between adjacent vertebrae after the intervertebral discs have been surgically cleared and the disc spaces filled with graft material. Due to limited availability of autograft, there is much current interest in the development of synthetic scaffolds in combination with growth factors such as recombinant human bone morphogenetic protein (rhBMP-2) to achieve a solid bony fusion following scoliosis surgery.

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ID Code: 47835
Item Type: Conference Paper
Additional URLs:
Keywords: biodegradable scaffold, polycaprolactone scaffold, intervertebral fusion, spinal deformity, bone morphogenetic protein, sheep thoracic spine
DOI: 10.1201/b11341-16
ISBN: 978-0-415-68418-7
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Medical Devices (090304)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Orthopaedics (110314)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2011 Taylor & Francis Group
Deposited On: 21 Dec 2011 08:43
Last Modified: 06 Dec 2012 03:43

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