Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model
Reichert, Johannes Christian (2010) Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model. PhD thesis, Queensland University of Technology.
Currently, well established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, their application, however, is associated with disadvantages. These include limited access and availability, donor site morbidity and haemorrhage, increased risk of infection, and insufficient transplant integration. As a result, recent research focuses on the development of complementary therapeutic concepts. The field of tissue engineering has emerged as an important alternative approach to bone regeneration. Tissue engineering unites aspects of cellular biology, biomechanical engineering, biomaterial sciences and trauma and orthopaedic surgery. To obtain approval by regulatory bodies for these novel therapeutic concepts the level of therapeutic benefit must be demonstrated rigorously in well characterized, clinically relevant animal models. Therefore, in this PhD project, a reproducible and clinically relevant, ovine, critically sized, high load bearing, tibial defect model was established and characterized as a prerequisite to assess the regenerative potential of a novel treatment concept in vivo involving a medical grade polycaprolactone and tricalciumphosphate based composite scaffold and recombinant human bone morphogenetic proteins.
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|Item Type:||QUT Thesis (PhD)|
|Supervisor:||Hutmacher, Dietmar, Schuetz, Michael, & Duda, Georg|
|Additional Information:||Embargoed until 26th May 2013.|
|Keywords:||bone, segmental defect, tibia, tissue engineering, scaffold, tricalciumphosphate, polycaprolactone, bone morphogenetic protein, osteoblasts, mesenchymal stem cells|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering|
Past > Schools > School of Engineering Systems
|Institution:||Queensland University of Technology|
|Deposited On:||16 Jan 2012 12:46|
|Last Modified:||06 Mar 2014 14:41|
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