Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model

Reichert, Johannes Christian (2010) Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model. PhD thesis, Queensland University of Technology.


Currently, well established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, their application, however, is associated with disadvantages. These include limited access and availability, donor site morbidity and haemorrhage, increased risk of infection, and insufficient transplant integration. As a result, recent research focuses on the development of complementary therapeutic concepts. The field of tissue engineering has emerged as an important alternative approach to bone regeneration. Tissue engineering unites aspects of cellular biology, biomechanical engineering, biomaterial sciences and trauma and orthopaedic surgery. To obtain approval by regulatory bodies for these novel therapeutic concepts the level of therapeutic benefit must be demonstrated rigorously in well characterized, clinically relevant animal models. Therefore, in this PhD project, a reproducible and clinically relevant, ovine, critically sized, high load bearing, tibial defect model was established and characterized as a prerequisite to assess the regenerative potential of a novel treatment concept in vivo involving a medical grade polycaprolactone and tricalciumphosphate based composite scaffold and recombinant human bone morphogenetic proteins.

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4 citations in Web of Science®
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ID Code: 48080
Item Type: QUT Thesis (PhD)
Supervisor: Hutmacher, Dietmar, Schuetz, Michael, & Duda, Georg
Additional Information: Embargoed until 26th May 2013.
Keywords: bone, segmental defect, tibia, tissue engineering, scaffold, tricalciumphosphate, polycaprolactone, bone morphogenetic protein, osteoblasts, mesenchymal stem cells
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > Schools > School of Engineering Systems
Institution: Queensland University of Technology
Deposited On: 16 Jan 2012 02:46
Last Modified: 28 Sep 2015 04:00

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