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Endogenous musculoskeletal tissue engineering : a focussed perspective

Adam, Clayton J. (2012) Endogenous musculoskeletal tissue engineering : a focussed perspective. Cell and Tissue Research, 347(3), pp. 489-499.

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Abstract

Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient’s autologous cells prior to re-implantation as part of a TE construct, and (2) the potential risks and availability constraints associated with transplanting exogenous (foreign) cells. These hurdles have led to recent interest in endogenous TE strategies, in which the regenerative potential of a patient’s own cells is harnessed to promote tissue regrowth without ex vivo cell culture. This article provides a focused perspective on key issues in the development of endogenous TE strategies, progress to date, and suggested future research directions toward endogenous repair and regeneration of musculoskeletal tissues and organs.

Impact and interest:

4 citations in Scopus
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4 citations in Web of Science®

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144 since deposited on 23 Jan 2012
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ID Code: 48173
Item Type: Journal Article
Keywords: tissue engineering, musculoskeletal system, endogenous, regeneration, cell homing
DOI: 10.1007/s00441-011-1234-2
ISSN: 1432-0878
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2011 Springer Berlin/Heidelberg.
Deposited On: 23 Jan 2012 10:00
Last Modified: 10 Nov 2013 19:17

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