Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives

Poole-Warren, L.A., Farrugia, B., Fong, N., Hume, E., & Simmons, A. (2008) Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives. Applied Surface Science, 255(2), pp. 519-522.

View at publisher


Polymer nanocomposites (NC) are fabricated by incorporating well dispersed nanoscale particles within a polymer matrix. This study focuses on elastomeric polyurethane (PU) based nanocomposites, containing organically modified silicates (OMS), as bioactive materials. Nanocomposites incorporating chlorhexidine diacetate as an organic modifier (OM) were demonstrated to be antibacterial with a dose dependence related to both the silicate loading and the loading of OM. When the non-antibacterial OM dodecylamine was used, both cell and platelet adhesion were decreased on the nanocomposite surface. These results suggest that OM is released from the polymer and can impact on cell behaviour at the interface. Nanocomposites have potential use as bioactive materials in a range of biomedical applications.

Impact and interest:

10 citations in Scopus
11 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 48442
Item Type: Journal Article
Refereed: Yes
Keywords: Polyurethane, Organosilicate, Biomaterial, Antibacterial, Platelet adhesion
DOI: 10.1016/j.apsusc.2008.06.062
ISSN: 0169-4332
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MEDICINAL AND BIOMOLECULAR CHEMISTRY (030400)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 05 Feb 2012 22:04
Last Modified: 29 Feb 2012 14:37

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page