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Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives

Poole-Warren, L.A., Farrugia, B., Fong, N., Hume, E., & Simmons, A. (2008) Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives. Applied Surface Science, 255(2), pp. 519-522.

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Abstract

Polymer nanocomposites (NC) are fabricated by incorporating well dispersed nanoscale particles within a polymer matrix. This study focuses on elastomeric polyurethane (PU) based nanocomposites, containing organically modified silicates (OMS), as bioactive materials. Nanocomposites incorporating chlorhexidine diacetate as an organic modifier (OM) were demonstrated to be antibacterial with a dose dependence related to both the silicate loading and the loading of OM. When the non-antibacterial OM dodecylamine was used, both cell and platelet adhesion were decreased on the nanocomposite surface. These results suggest that OM is released from the polymer and can impact on cell behaviour at the interface. Nanocomposites have potential use as bioactive materials in a range of biomedical applications.

Impact and interest:

9 citations in Scopus
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6 citations in Web of Science®

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ID Code: 48442
Item Type: Journal Article
Keywords: Polyurethane, Organosilicate, Biomaterial, Antibacterial, Platelet adhesion
DOI: 10.1016/j.apsusc.2008.06.062
ISSN: 0169-4332
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MEDICINAL AND BIOMOLECULAR CHEMISTRY (030400)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 05 Feb 2012 22:04
Last Modified: 29 Feb 2012 14:37

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