Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives
Poole-Warren, L.A., Farrugia, B., Fong, N., Hume, E., & Simmons, A. (2008) Controlling cell-material interactions with polymer nanocomposites by use of surface modifying additives. Applied Surface Science, 255(2), pp. 519-522.
Polymer nanocomposites (NC) are fabricated by incorporating well dispersed nanoscale particles within a polymer matrix. This study focuses on elastomeric polyurethane (PU) based nanocomposites, containing organically modified silicates (OMS), as bioactive materials. Nanocomposites incorporating chlorhexidine diacetate as an organic modifier (OM) were demonstrated to be antibacterial with a dose dependence related to both the silicate loading and the loading of OM. When the non-antibacterial OM dodecylamine was used, both cell and platelet adhesion were decreased on the nanocomposite surface. These results suggest that OM is released from the polymer and can impact on cell behaviour at the interface. Nanocomposites have potential use as bioactive materials in a range of biomedical applications.
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|Item Type:||Journal Article|
|Keywords:||Polyurethane, Organosilicate, Biomaterial, Antibacterial, Platelet adhesion|
|Subjects:||Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MEDICINAL AND BIOMOLECULAR CHEMISTRY (030400)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering|
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||06 Feb 2012 08:04|
|Last Modified:||01 Mar 2012 00:37|
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