Immunohistochemical detection of survivin in canine lymphoma

Wimmershoff, Julia, Polkinghorne, Adam, Grest, Paula, Schade, Benjamin, Marchal, T, Keller, Stefan, & Guscetti, Franco (2010) Immunohistochemical detection of survivin in canine lymphoma. Journal of Comparative Pathology, 142(4), pp. 311-322.

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Survivin is a member of the family of proteins known as 'inhibitors of apoptosis proteins'. Survivin has a role in cellular decisions concerning division and survival and is frequently expressed in neoplastic cells. The aim of the present study was to investigate immunohistochemically the expression of survivin in normal canine tissues and in canine lymphoma. A representative range of fetal and adult normal tissues as well as biopsy samples from dogs with lymphoma were assembled in tissue arrays. The lymphomas were classified according to the revised Kiel and to the Revised European American Lymphoma - World Health Organization (REAL-WHO) schemes. Polyclonal and monoclonal antisera cross-reactive with canine survivin identified cytoplasmic expression of the molecule in a broad range of normal canine cells. The same reagents demonstrated cytoplasmic labelling of more than 5% of cells in all 83 lymphoma samples tested with polyclonal antiserum and in 67 of 82 (82%) of samples tested with monoclonal antiserum. Survivin was expressed by a wide range of canine lymphoma subtypes, but the expression of this molecule in normal canine tissues must be considered if novel therapies targeting survivin are applied to the management of canine lymphoma. © 2010 Elsevier Ltd.

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6 citations in Scopus
6 citations in Web of Science®
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ID Code: 48644
Item Type: Journal Article
Refereed: Yes
Keywords: dog, immunohistochemistry, lymphoma, survivin
DOI: 10.1016/j.jcpa.2009.12.004
ISSN: 0021-9975
Subjects: Australian and New Zealand Standard Research Classification > AGRICULTURAL AND VETERINARY SCIENCES (070000) > VETERINARY SCIENCES (070700)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 15 Feb 2012 22:27
Last Modified: 29 Feb 2012 14:37

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