H. pylori-infection and antibody immune response in a rural Tanzanian population

Mbulaiteye, Sam M, Gold, Benjamin D, Pfeiffer, Ruth M, Brubaker, Glen R, Shao, John, Biggar, Robert J, & Hisada, Michie (2006) H. pylori-infection and antibody immune response in a rural Tanzanian population. Infectious Agents and Cancer, 1(1), 3pg.

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Abstract Background: Helicobacter pylori (H. pylori) infection is ubiquitous in sub-Saharan Africa, but paradoxically gastric cancer is rare. Methods: Sera collected during a household-based survey in rural Tanzania in 1985 were tested for anti-H. pylori IgG and IgG subclass antibodies by enzyme immunoassay. Odds ratios (OR) and confidence intervals (CI) of association of seropositivity with demographic variables were computed by logistic regression models. Results: Of 788 participants, 513 were aged ≤17 years. H. pylori seropositivity increased from 76% at 0–4 years to 99% by ≥18 years of age. Seropositivity was associated with age (OR 11.5, 95% CI 4.2–31.4 for 10–17 vs. 0–4 years), higher birth-order (11.1; 3.6–34.1 for ≥3rd vs. 1st born), and having a seropositive next-older sibling (2.7; 0.9–8.3). Median values of IgG subclass were 7.2 for IgG1 and 2.0 for IgG2. The median IgG1/IgG2 ratio was 3.1 (IQR: 1.7–5.6), consistent with a Th2- dominant immune profile. Th2-dominant response was more frequent in children than adults (OR 2.4, 95% CI 1.3–4.4). Conclusion: H. pylori seropositivity was highly prevalent in Tanzania and the immunological response was Th2-dominant. Th2-dominant immune response, possibly caused by concurrent bacterial or parasitic infections, could explain, in part, the lower risk of H. pylori-associated gastric cancer in Africa.

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ID Code: 49771
Item Type: Journal Article
Refereed: Yes
DOI: 10.1186/1750-9378-1-3
ISSN: 17509378
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Mbulaiteye et al
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Deposited On: 18 Apr 2012 04:34
Last Modified: 18 Apr 2012 04:34

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